Fasudil Hydrochloride Injection
Complete
The main ingredient of this product is Fasunur hydrochloride, and its chemical name is: hexal-1- (5-sulfonyl albumin) -1 (H) -1,4-two-nitrogen hydrochloride hydrochloride.
Its structural formula is:
Shape * MergeFormat
Molecular formula: C14H17N3O2S · HCL
Molecular weight: 327.83
Auxiliary materials: injection of water.
Character Character
This product is colorless to slightly yellow clear liquid.
Indications
Improve and prevent cerebral vascular spasm after the hyperemia and the symptoms of cerebral ischemia caused by it.
Specification
2ml: 30mg
Dosage
Adults 30 mg each time, 2 to 3 times a day, diluted with 50-100ml physiological saline or glucose injection, and then dripped after the vein, each time the drip time is 30 minutes.
This product should start in the early stages of the subarachnoid hemorrhage, which is used for 2 weeks.
Adverse reactions
1. Sometimes intracranial hemorrhage (1.63%)
2. Sometimes gastrointestinal bleeding, lung bleeding, nosebleeds, subcutaneous bleeding (0.29%) and other bleeding. Pay attention to observation. If abnormalities occur, the drug should be discontinued and appropriately disposal.
3. Circular system: Occasionally hypotension, flushing face.
4. Blood system: occasionally anemia, white blood cells, platelets decrease.
5. Sometimes liver function is abnormal. Skymen amino aminotransferase (AST), Alanine amin aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) elevation, etc.
6. Urinary system: occasionally abnormal renal function (urea nitrogen (BUN), higher creatinine), and polyuria.
7. Gastrointestinal: Abdominal distension, nausea, vomiting and other rare.
8. Allergy: Occasionally allergic symptoms such as rash.
9. Others: fever (occasionally), headache, low consciousness, respiratory suppression (rare).
Taboo
The following patients disable this product:
1. Bleeding patients: intracranial hemorrhage.
2. Patients with intracranial hemorrhage may occur: patients who fail to suffer sufficient hemostatic treatment of the aneurysm of bleeding during the operation.
3. Patients with low blood pressure.
Precautions
1. This product can only be used by intravenously, and cannot be administered in other ways. The following patients should be used with caution:
(1) Patients with diabetes before surgery. Patients with arteriosclerosis in the main arteries during the surgery should fully observe clinical symptoms and computer fault photography. If intracranial hemorrhage is found, the drug should be discontinued and appropriately disposed of;
(2) Patients with renal dysfunction (for example, 10mg at a time);
(3) Patients with liver dysfunction (may delay metabolism, increase blood concentration and enhance the effect);
(4) Patients with severe consciousness disorder (less experience, has not yet established validity);
(5) Elderly patients over 70 years of age (may improve the prognosis function, which may not be effective, and have not yet established effectiveness);
(6) Patients (smoke disease, huge cerebral aneurysm, etc.) (no experience, and safety) in patients with hyperemiam hemorrhage and severe cerebrovascular disorders (smoke disease, huge cerebral aneurysm, etc.).
2. When using this product, pay close attention to clinical symptoms and CT changes. If intracranial hemorrhage is found, the drug should be discontinued immediately and properly treated.
3. This product can cause hypotension, so you should pay attention to blood pressure changes and administration speed during medication.
4. The medication time for this product is 2 weeks and cannot be used for a long time.
[Medication of pregnant women and lactating women]
Pregnancy or maybe pregnant women and lactating women should avoid using it.
Children's medication
The safety of children's medication has not been established.
Old Medicine
Elderly patients over 70 years of age should be used with caution.
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